Positive regulation of protein-containing complex disassembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein-containing complex disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NES, NES_S680, and NES_S1030, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein-containing complex disassembly activity versus NES in HNSC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NES →	+0.747	+0.837	<.001	<.001	3	7
BRCA	NES_S680 →	+0.912	+1.009	<.001	<.001	3	6
BRCA	NES_S1030 →	+1.072	+1.625	<.001	<.001	3	5
HNSC	NES_S352 →	+1.529	+1.174	<.001	<.001	3	5
HNSC	NES_S768 →	+1.174	+1.361	<.001	<.001	3	5
HNSC	NES_T338 →	+0.930	+1.287	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043243 vs NES — HNSC

Explore this scatter interactively →