Positive regulation of protein-containing complex disassembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRARP, SEC22C, and CDC16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NRARP grouped by Positive regulation of protein-containing complex disassembly-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NRARP →	+0.820	+0.635	.002	.001	3	5
BONE	SEC22C →	-0.599	-0.233	.002	.005	3	4
LUNG_NSCLC_LUSC	CDC16 →	-0.745	-0.291	<.001	.001	3	4
LUNG_NSCLC_LUSC	LOXL2 →	-3.673	-0.358	.001	<.001	3	4
LUNG_NSCLC_LUSC	PRRG4 →	+1.918	+0.369	.002	.002	3	4
LUNG_NSCLC_LUSC	OSBPL5 →	-1.365	-0.309	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NRARP by Positive regulation of protein-containing complex disassembly activity — OVARY

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