Positive regulation of protein-containing complex disassembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT-CO1, MT-ND4, and ABHD17C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein-containing complex disassembly activity versus MT-CO1 in LARGE_INTESTINE (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MT-CO1 →	-0.686	-0.218	.006	.007	3	4
LARGE_INTESTINE	MT-ND4 →	-0.688	-0.242	.006	.007	2	5
BLOOD_Lymphoma	ABHD17C →	-1.467	-0.164	.005	.007	3	4
LUNG_NSCLC_LUSC	CCDC115 →	+0.730	+0.395	<.001	<.001	3	4
LIVER	ABCA1 →	+1.492	+0.498	.007	.003	2	5
LUNG_NSCLC_LUSC	CREB3L1 →	+2.398	+0.366	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043243 vs MT-CO1 — LARGE_INTESTINE

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