Negative regulation of protein-containing complex disassembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein-containing complex disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2, MAP1A, and VCL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein-containing complex disassembly activity versus SYNPO2 in UCEC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO2 →	+0.781	+0.051	.003	<.001	3	9
HNSC	MAP1A →	+0.543	+0.046	<.001	<.001	3	9
UCEC	VCL →	+0.574	+0.047	.001	<.001	3	8
UCEC	CALD1 →	+0.781	+0.047	<.001	<.001	3	8
BRCA	CNN3 →	+0.440	+0.026	<.001	<.001	3	8
PDAC	RPL5 →	-0.160	-0.041	.004	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043242 vs SYNPO2 — UCEC

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