Negative regulation of protein-containing complex disassembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMDS, DPF1, and ASPHD2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein-containing complex disassembly activity versus GMDS in BRCA (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GMDS →	-1.308	-0.433	.007	.004	3	1
BRCA	DPF1 →	-0.403	-0.433	.009	.004	3	1
BRCA	ASPHD2 →	-0.569	-0.360	.001	.007	3	1
BRCA	BST2 →	-2.450	-0.433	.003	.004	3	1
BRCA	FMO5 →	-1.355	-0.433	<.001	.004	3	1
BRCA	NES →	+1.383	+0.434	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043242 vs GMDS — BRCA

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