Response to L-leucine

Across TCGA cell cohorts, RNA activity of the Response to L-leucine pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCYL1, NME6, and RPTOR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCYL1 grouped by Response to L-leucine-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SCYL1 →	+0.420	+0.216	.001	.005	3	4
BLOOD_Leukemia	NME6 →	-0.176	-1.167	.001	.001	3	3
BLOOD_Leukemia	RPTOR →	-0.224	-1.123	.005	.002	3	3
SKIN	ZFHX4 →	-0.161	-0.266	.008	.003	3	3
BLOOD_Leukemia	RAD9A →	-0.236	-1.496	.001	.002	3	2
BLOOD_Leukemia	GYPB →	+0.362	+1.531	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCYL1 by Response to L-leucine activity — BLOOD_Lymphoma

Explore this box plot interactively →