Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCOR3, RPS2, and RPS3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway activity versus RCOR3 in PDAC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RCOR3 →	+0.140	+0.025	.003	<.001	3	5
PDAC	RPS2 →	-0.309	-0.042	<.001	<.001	3	5
LUAD	RPS3A →	-0.166	-0.029	.001	.003	3	5
GBM	RPL3 →	-0.314	-0.037	<.001	.002	3	5
GBM	RPS28 →	-0.227	-0.045	.001	.003	3	5
GBM	RPS5 →	-0.217	-0.048	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043162 vs RCOR3 — PDAC

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