Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN23, TSG101, and VPS28, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN23 grouped by Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PTPN23 →	-0.384	-0.450	<.001	.006	3	6
LARGE_INTESTINE	TSG101 →	-0.430	-0.298	.008	.001	3	6
BREAST	VPS28 →	-0.475	-0.438	<.001	.005	3	5
BREAST	HGS →	-0.290	-0.337	<.001	.002	3	5
SKIN	HCLS1 →	+0.108	+0.149	.003	.004	3	5
OVARY	HMCN1 →	-0.280	-0.287	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN23 by Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway activity — BREAST

Explore this box plot interactively →