Stress fiber assembly

Across TCGA patient cohorts, RNA activity of the Stress fiber assembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F1, KLF9, and GNAI1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress fiber assembly activity versus E2F1 in COAD (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	E2F1 →	-0.547	-1.167	.008	<.001	3	2
COAD	KLF9 →	+0.807	+0.854	<.001	.008	3	2
BRCA	GNAI1 →	+0.969	+0.336	<.001	<.001	3	2
COAD	CPNE8 →	+0.496	+1.184	.005	<.001	3	2
BRCA	HPGDS →	+1.737	+0.521	.001	<.001	3	2
COAD	MTMR10 →	+0.462	+1.045	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043149 vs E2F1 — COAD

Explore this scatter interactively →