NAD transport

Across TCGA patient cohorts, RNA activity of the NAD transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LSP1, RSL1D1, and TBC1D2B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NAD transport activity versus LSP1 in OV (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LSP1 →	+0.523	+0.055	.004	.005	3	8
BRCA	RSL1D1 →	-0.415	-0.046	.006	<.001	3	7
PDAC	TBC1D2B →	+0.218	+0.049	<.001	.001	3	7
LUAD	EVL_S246 →	+0.448	+0.050	<.001	<.001	3	7
COAD	OPTN →	+0.224	+0.033	<.001	<.001	3	7
BRCA	YME1L1 →	-0.313	-0.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043132 vs LSP1 — OV

Explore this scatter interactively →