Surfactant homeostasis

Across TCGA cell cohorts, RNA activity of the Surfactant homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HERPUD1, CNTN6, and NCSTN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HERPUD1 grouped by Surfactant homeostasis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HERPUD1 →	-0.175	-1.383	.002	<.001	3	3
LARGE_INTESTINE	CNTN6 →	-0.126	-1.832	.002	<.001	3	2
SKIN	NCSTN →	+0.366	+1.995	.006	.003	3	2
LUNG_NSCLC_LUAD	ALG5 →	+0.075	+1.339	.007	.005	3	2
LUNG_NSCLC_LUAD	ACP2 →	-0.236	-1.904	.004	<.001	3	2
LUNG_NSCLC_LUAD	ZSWIM1 →	-0.247	-2.002	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HERPUD1 by Surfactant homeostasis activity — BREAST

Explore this box plot interactively →