Negative regulation of canonical NF-kappaB signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of canonical NF-kappaB signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINB9, TLN1, and COLEC12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of canonical NF-kappaB signal transduction activity versus SERPINB9 in LUAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SERPINB9 →	+0.394	+0.039	<.001	<.001	3	6
LUAD	TLN1 →	+0.208	+0.028	<.001	.002	3	6
GBM	COLEC12 →	+0.557	+0.043	.009	.008	3	6
GBM	GIMAP1 →	+0.335	+0.049	<.001	<.001	3	6
BRCA	ILK →	+0.357	+0.040	<.001	<.001	3	6
GBM	TBC1D2B →	+0.211	+0.043	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043124 vs SERPINB9 — LUAD

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