Negative regulation of canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBG2, HERPUD1, and ELMO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBG2 grouped by Negative regulation of canonical NF-kappaB signal transduction-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TUBG2 →	+1.446	+0.288	.007	<.001	3	4
BLOOD_Lymphoma	HERPUD1 →	+1.105	+0.227	.005	.005	3	4
STOMACH	ELMO2 →	+0.958	+0.214	.001	.001	3	3
PANCREAS	H1-2 →	+1.218	+0.164	.004	.009	2	4
STOMACH	MYCL →	+1.795	+0.274	.002	.002	3	3
BLOOD_Myeloma	BTBD3 →	+3.506	+0.317	.004	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBG2 by Negative regulation of canonical NF-kappaB signal transduction activity — STOMACH

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