Negative regulation of canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of canonical NF-kappaB signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOD1, NAALADL2, and PCDH9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYOD1 grouped by Negative regulation of canonical NF-kappaB signal transduction-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MYOD1 →	+0.156	+0.354	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	NAALADL2 →	+0.345	+1.563	.003	<.001	3	4
KIDNEY	PCDH9 →	-0.227	-0.337	.001	.003	3	4
URINARY_TRACT	MSL3 →	+0.520	+0.257	.004	.002	3	3
LARGE_INTESTINE	MTA2 →	+0.230	+0.190	.001	.006	3	3
OVARY	CD3E →	+0.243	+0.265	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYOD1 by Negative regulation of canonical NF-kappaB signal transduction activity — OVARY

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