Negative regulation of canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POF1B, TBC1D4, and HACD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of canonical NF-kappaB signal transduction activity versus POF1B in LUNG_NSCLC_LUAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	POF1B →	+0.992	+0.420	.001	.003	3	5
BLOOD_Leukemia	TBC1D4 →	-1.617	-0.148	.002	.002	3	4
LARGE_INTESTINE	HACD1 →	-1.126	-0.289	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	CARS1 →	-0.538	-0.949	.002	.002	3	4
LARGE_INTESTINE	HNF1A →	+2.638	+0.411	<.001	.006	3	4
LARGE_INTESTINE	FRMD6 →	-1.675	-0.291	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043124 vs POF1B — LUNG_NSCLC_LUAD

Explore this scatter interactively →