Positive regulation of canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INAFM2, B4GALT5, and CDKN1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INAFM2 grouped by Positive regulation of canonical NF-kappaB signal transduction-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	INAFM2 →	+0.906	+0.156	<.001	.004	3	5
LIVER	B4GALT5 →	+0.803	+0.172	.006	.003	3	5
LARGE_INTESTINE	CDKN1A →	-2.517	-0.154	<.001	.001	3	4
BONE	DPP3 →	+1.096	+0.127	.003	.008	3	4
BONE	F8A3 →	+1.984	+0.155	.001	.002	3	4
LARGE_INTESTINE	MECP2 →	+0.842	+0.120	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INAFM2 by Positive regulation of canonical NF-kappaB signal transduction activity — STOMACH

Explore this box plot interactively →