Positive regulation of vascular permeability

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular permeability pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDE3A, XRN2, and PDE3A_S312, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular permeability activity versus PDE3A in LUAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PDE3A →	+0.522	+0.046	<.001	<.001	3	7
LSCC	XRN2 →	-0.194	-0.043	<.001	<.001	3	6
GBM	PDE3A_S312 →	+0.567	+0.046	<.001	.001	3	6
LSCC	COL14A1 →	+0.710	+0.047	<.001	<.001	3	6
CCRCC	RANGAP1 →	-0.161	-0.058	<.001	<.001	3	6
COAD	A1BG →	+0.534	+0.029	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043117 vs PDE3A — LUAD

Explore this scatter interactively →