Positive regulation of vascular permeability

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of vascular permeability pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Positive regulation of vascular permeability pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and KIRP, show the opposite pattern, with higher activity associated with better survival.

BLCA, LAML, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	All	0.614	0.419	.003	51	view →
LAML	DFS	Median	All	0.211	0.496	<.001	42	view →
ACC	DFS	Quartile	All	0.158	0.571	.004	41	view →
CESC	DFS	Median	All	0.396	0.654	<.001	38	view →
KIRP	DFS	Median	IV	0.686	0.039	<.001	30	view →
SCLC	OS	Tertile	All	0.634	0.215	.001	29	view →
HNSC	OS	Median	III,IV	0.477	0.299	.024	17	view →
TGCT	DFS	Quartile	II,III,IV	0.053	1.000	.001	12	view →
KIRC	DFS	Median	III,IV	0.709	0.583	.010	12	view →
THCA	OS	Median	II,III,IV	0.946	0.808	.012	12	view →
LGG	OS	Median	All	0.854	0.769	.010	11	view →
LIHC	OS	Tertile	III,IV	0.341	0.574	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0043117–BLCA (DFS)

Open the BLCA breakdown →