Positive regulation of vascular permeability

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular permeability pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UNC13B, ATP8B1, and GPD1L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular permeability activity versus UNC13B in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UNC13B →	+0.614	+0.380	.002	<.001	3	6
BRCA	ATP8B1 →	+1.197	+0.658	<.001	<.001	3	6
UCEC	GPD1L →	+0.692	+0.746	.001	.003	3	6
PDAC	FPR2 →	-0.862	-0.883	<.001	.001	3	6
COAD	GGT6 →	+1.197	+0.812	<.001	.001	2	7
PDAC	BCAS1 →	+1.602	+1.067	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043117 vs UNC13B — HNSC

Explore this scatter interactively →