Positive regulation of vascular permeability

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular permeability pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3C8, RAPGEF3, and RMND5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular permeability activity versus H3C8 in SOFT_TISSUE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H3C8 →	+0.726	+1.575	.004	.002	3	4
SOFT_TISSUE	RAPGEF3 →	+2.495	+1.419	.008	.008	3	3
BONE	RMND5A →	-1.004	-1.380	.001	<.001	3	3
PANCREAS	ZNF25 →	-0.778	-0.365	<.001	.009	3	3
OESOPHAGUS	DNAH5 →	+1.018	+0.295	.004	.003	2	4
UPPER_AERODIGESTIVE_TRACT	TMEM18 →	-0.807	-0.208	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043117 vs H3C8 — SOFT_TISSUE

Explore this scatter interactively →