Amino acid salvage

Across TCGA cell cohorts, RNA activity of the Amino acid salvage pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF2, NRF1, and SAFB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHF2 grouped by Amino acid salvage-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PHF2 →	-0.519	-0.710	.003	.004	3	5
OVARY	NRF1 →	-0.368	-1.179	.002	.006	3	4
BONE	SAFB →	-0.599	-1.353	.007	<.001	1	6
LUNG_SCLC	KCNRG →	-0.650	-1.399	<.001	.001	3	4
BLOOD_Myeloma	CTAGE15 →	+0.068	+1.361	.009	.004	2	5
LUNG_NSCLC_LUAD	DAZAP1 →	-0.339	-0.816	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHF2 by Amino acid salvage activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →