Purine-containing compound salvage

Across TCGA patient cohorts, RNA activity of the Purine-containing compound salvage pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP8, TXK, and CLEC10A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine-containing compound salvage activity versus GIMAP8 in HNSC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GIMAP8 →	+0.679	+0.086	<.001	.004	3	5
LUAD	TXK →	+0.365	+0.103	.001	<.001	3	5
HNSC	CLEC10A →	+0.649	+0.080	.007	.008	3	5
HNSC	TLR1 →	+0.562	+0.147	.007	<.001	3	5
HNSC	TRBV9 →	+0.701	+0.130	<.001	<.001	3	5
LUAD	IL2RB →	+0.602	+0.119	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043101 vs GIMAP8 — HNSC

Explore this scatter interactively →