Purine-containing compound salvage

Across TCGA pan-cancer cohorts, RNA activity of the Purine-containing compound salvage pathway is associated with patient survival in 30 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Purine-containing compound salvage pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and ESCA, show the opposite pattern, with higher activity associated with better survival.

LIHC, UCEC, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.396	0.583	<.001	95	view →
UCEC	DFS	Quartile	All	0.604	0.832	<.001	94	view →
UVM	DFS	Tertile	III,IV	0.241	0.929	<.001	75	view →
LUAD	DFS	Tertile	All	0.706	0.850	<.001	66	view →
KIRC	OS	Median	All	0.554	0.722	<.001	65	view →
KIRP	OS	Quartile	All	0.665	0.838	.003	46	view →
THCA	OS	Quartile	III,IV	0.866	1.000	.001	45	view →
STAD	DFS	Quartile	All	0.199	0.617	.002	44	view →
CHOL	OS	Tertile	All	0.273	0.665	.007	29	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
ESCA	OS	Tertile	IV	0.743	0.290	.013	24	view →
OV	OS	Tertile	IV	0.805	0.457	.002	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

GO:0043101–LIHC (OS)

Open the LIHC breakdown →