Purine-containing compound salvage

Across TCGA cell cohorts, RNA activity of the Purine-containing compound salvage pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD82, TSC22D4, and CCNE2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD82 grouped by Purine-containing compound salvage-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD82 →	+2.561	+0.954	<.001	.002	3	4
SOFT_TISSUE	TSC22D4 →	-0.780	-1.020	.008	.003	3	4
BLOOD_Myeloma	CCNE2 →	+1.915	+1.701	.004	<.001	3	4
KIDNEY	SMARCA1 →	-1.431	-1.088	.001	.008	3	3
KIDNEY	CPM →	-2.236	-1.033	.004	.007	2	4
STOMACH	UBE2E2 →	-4.356	-0.418	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD82 by Purine-containing compound salvage activity — BLOOD_Leukemia

Explore this box plot interactively →