Purine-containing compound salvage

Across TCGA cell cohorts, RNA activity of the Purine-containing compound salvage pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3A, MFAP5, and NDUFB10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine-containing compound salvage activity versus RAB3A in LARGE_INTESTINE (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAB3A →	+0.869	+0.866	.006	.004	3	6
OESOPHAGUS	MFAP5 →	-2.293	-1.493	.009	<.001	3	5
BLOOD_Lymphoma	NDUFB10 →	+0.573	+0.199	.002	<.001	1	7
BLOOD_Lymphoma	RGS16 →	+2.790	+0.283	.006	<.001	2	6
LIVER	LAMA3 →	-2.680	-1.538	<.001	<.001	3	5
PANCREAS	DCAF13 →	+0.812	+1.631	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043101 vs RAB3A — LARGE_INTESTINE

Explore this scatter interactively →