Amino acid activation

Across TCGA patient cohorts, RNA activity of the Amino acid activation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF638, SART3, and SPAG9_T1264, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid activation activity versus ZNF638 in LSCC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF638 →	+0.282	+0.035	<.001	.001	3	5
PDAC	SART3 →	+0.157	+0.023	<.001	<.001	3	5
OV	SPAG9_T1264 →	-0.651	-0.041	.006	.006	3	5
UCEC	AHNAK2_S365 →	-1.083	-0.126	<.001	<.001	3	5
LSCC	STIM1_S257 →	-0.459	-0.031	<.001	.001	3	5
GBM	ZC3HAV1_S335 →	-0.316	-0.022	.003	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043038 vs ZNF638 — LSCC

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