Amino acid activation

Across TCGA patient cohorts, RNA activity of the Amino acid activation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, ZNF25, and DCN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid activation activity versus CNRIP1 in OV (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNRIP1 →	-0.855	-0.210	<.001	<.001	3	7
UCEC	ZNF25 →	-0.478	-0.203	.003	<.001	3	7
OV	DCN →	-1.023	-0.135	.001	.002	3	6
OV	NCF2 →	-0.843	-0.177	.001	<.001	3	6
OV	MYCT1 →	-0.554	-0.220	.002	<.001	3	6
OV	RHOJ →	-0.831	-0.272	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043038 vs CNRIP1 — OV

Explore this scatter interactively →