Positive regulation of macrophage activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLRP3, C5AR1, and CASS4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macrophage activation activity versus NLRP3 in GBM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NLRP3 →	+0.734	+0.766	.001	<.001	3	6
GBM	C5AR1 →	+0.964	+0.610	<.001	.001	3	5
HNSC	CASS4 →	+0.607	+0.270	<.001	<.001	3	5
GBM	LIPN →	+0.346	+0.664	.001	<.001	3	5
PDAC	C3orf86 →	+0.397	+0.150	.001	.002	3	5
GBM	HAMP →	+1.089	+0.610	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043032 vs NLRP3 — GBM

Explore this scatter interactively →