Golgi to plasma membrane protein transport

Across TCGA patient cohorts, RNA activity of the Golgi to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCA, PRSS8, and CENPI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to plasma membrane protein transport activity versus FANCA in BRCA (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FANCA →	-0.650	-0.216	<.001	<.001	3	5
BRCA	PRSS8 →	+0.830	+0.188	.002	<.001	3	5
UCEC	CENPI →	-0.775	-0.129	<.001	.007	3	5
UCEC	POLQ →	-1.000	-0.163	<.001	.001	3	5
BRCA	E2F3 →	-0.796	-0.278	<.001	<.001	3	5
BRCA	LGALS3 →	+0.488	+0.188	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043001 vs FANCA — BRCA

Explore this scatter interactively →