Golgi to plasma membrane protein transport

Across TCGA cell cohorts, RNA activity of the Golgi to plasma membrane protein transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM15, TMEM199, and GCLC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM15 grouped by Golgi to plasma membrane protein transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRIM15 →	-0.210	-0.293	.005	.005	3	4
LUNG_SCLC	TMEM199 →	-0.226	-0.311	.001	.001	3	4
LUNG_SCLC	GCLC →	-0.214	-0.312	.001	<.001	3	3
LUNG_SCLC	GORAB →	-0.273	-0.312	.001	.009	3	3
LUNG_SCLC	CLDN14 →	-0.254	-0.330	.003	.006	3	3
LUNG_SCLC	NAXE →	-0.186	-0.294	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM15 by Golgi to plasma membrane protein transport activity — LUNG_SCLC

Explore this box plot interactively →