Positive regulation of Golgi to plasma membrane protein transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of Golgi to plasma membrane protein transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAXE, PRUNE1, and RCOR3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Golgi to plasma membrane protein transport activity versus NAXE in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NAXE →	+0.473	+0.057	<.001	<.001	3	8
UCEC	PRUNE1 →	+0.474	+0.096	<.001	<.001	3	8
HNSC	RCOR3 →	+0.522	+0.094	<.001	<.001	3	7
LUAD	TPI1_S80 →	-0.643	-0.049	<.001	.001	3	7
UCEC	BROX →	+0.557	+0.089	<.001	<.001	3	7
LUAD	RPRD2_S485 →	+0.428	+0.034	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042998 vs NAXE — BRCA

Explore this scatter interactively →