Positive regulation of Golgi to plasma membrane protein transport

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of Golgi to plasma membrane protein transport pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Positive regulation of Golgi to plasma membrane protein transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRP, ACC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.516	0.846	<.001	103	view →
ACC	DFS	Tertile	III,IV	0.584	0.198	.005	48	view →
HNSC	OS	Median	IV	0.674	0.529	.005	39	view →
UCS	DFS	Median	II,III,IV	0.125	0.428	.001	26	view →
DLBC	OS	Tertile	All	0.277	0.956	.002	24	view →
KIRC	DFS	Median	IV	0.764	0.506	.009	23	view →
SKCM	OS	Tertile	II,III,IV	0.485	0.317	.013	21	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	15	view →
ESCA	DFS	Quartile	All	0.380	0.633	.002	15	view →
PAAD	DFS	Median	II,III,IV	0.534	0.394	.022	14	view →
THYM	OS	Median	All	1.000	0.750	.002	14	view →
BRCA	DFS	Quartile	IV	0.763	0.254	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0042998–KIRP (OS)

Open the KIRP breakdown →