Positive regulation of Golgi to plasma membrane protein transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of Golgi to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKT3, CNRIP1, and MYCBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Golgi to plasma membrane protein transport activity versus AKT3 in UCEC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKT3 →	-0.672	-0.075	.002	.006	3	3
GBM	CNRIP1 →	-0.598	-0.158	.007	.004	3	3
UCEC	MYCBP2 →	-0.347	-0.191	.005	.007	3	3
COAD	AMZ2P2 →	+0.060	+0.123	.001	<.001	3	3
COAD	H2BW3P →	-0.294	-0.122	<.001	<.001	3	3
GBM	PODN →	-0.697	-0.132	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042998 vs AKT3 — UCEC

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