Positive regulation of Golgi to plasma membrane protein transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of Golgi to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSL3, GRK6, and CHMP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Golgi to plasma membrane protein transport activity versus ACSL3 in LUNG_NSCLC_LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ACSL3 →	+0.835	+0.193	.001	<.001	3	5
BLOOD_Leukemia	GRK6 →	+0.517	+0.170	.003	<.001	3	4
SKIN	CHMP5 →	-0.581	-0.207	.001	<.001	3	4
OVARY	LMX1B →	+1.260	+0.187	.001	<.001	3	4
BONE	FICD →	-0.867	-0.210	.003	.003	3	4
LUNG_SCLC	SLC15A2 →	-0.594	-0.148	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042998 vs ACSL3 — LUNG_NSCLC_LUAD

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