Amyloid precursor protein catabolic process

Across TCGA patient cohorts, RNA activity of the Amyloid precursor protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAA50, RPUSD2_S68, and STAB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid precursor protein catabolic process activity versus NAA50 in BRCA (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NAA50 →	-0.278	-0.039	<.001	<.001	3	7
LSCC	RPUSD2_S68 →	-0.432	-0.061	<.001	<.001	3	6
LSCC	STAB1 →	+0.441	+0.051	<.001	<.001	3	6
BRCA	YME1L1 →	-0.284	-0.026	.001	.005	3	6
GBM	G3BP1 →	-0.236	-0.060	.001	<.001	3	6
OV	PAICS →	-0.317	-0.030	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042987 vs NAA50 — BRCA

Explore this scatter interactively →