Amyloid precursor protein catabolic process

Across TCGA patient cohorts, RNA activity of the Amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RA, SLC16A8, and DHX35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid precursor protein catabolic process activity versus CSF2RA in LSCC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSF2RA →	+0.344	+0.128	.006	.001	3	5
CCRCC	SLC16A8 →	-0.563	-0.238	<.001	<.001	3	4
CCRCC	DHX35 →	-0.194	-0.183	.002	.001	3	4
CCRCC	VIPAS39 →	-0.222	-0.192	.009	.001	3	4
LSCC	MAST1 →	-0.332	-0.133	.002	.006	3	4
HNSC	CENPM →	-0.824	-0.148	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042987 vs CSF2RA — LSCC

Explore this scatter interactively →