Amyloid precursor protein catabolic process

Across TCGA cell cohorts, RNA activity of the Amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF81, TRIM73, and PPP1R14C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF81 grouped by Amyloid precursor protein catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF81 →	-0.787	-1.067	.001	<.001	3	4
OVARY	TRIM73 →	+1.190	+0.891	<.001	<.001	3	4
BLOOD_Lymphoma	PPP1R14C →	-0.357	-1.970	.007	<.001	3	4
LUNG_NSCLC_LUSC	PLTP →	+4.153	+1.083	.001	.009	3	4
BLOOD_Myeloma	ACADM →	+1.144	+1.275	<.001	<.001	3	4
CNS	DDX56 →	-0.483	-1.121	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF81 by Amyloid precursor protein catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →