Amyloid precursor protein catabolic process

Across TCGA cell cohorts, RNA activity of the Amyloid precursor protein catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASQ2, BRAF, and COX6A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CASQ2 grouped by Amyloid precursor protein catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CASQ2 →	+0.098	+0.249	<.001	.005	3	3
LUNG_NSCLC_LUAD	BRAF →	+0.137	+0.365	.001	.006	3	3
URINARY_TRACT	COX6A1 →	-0.360	-0.437	.009	.002	3	3
URINARY_TRACT	SRSF6 →	-0.266	-0.437	<.001	.002	3	3
URINARY_TRACT	IPO4 →	+0.367	+0.327	.001	.002	3	3
LIVER	CLCN5 →	+0.316	+0.431	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CASQ2 by Amyloid precursor protein catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →