ATP synthesis coupled electron transport

Across TCGA patient cohorts, RNA activity of the ATP synthesis coupled electron transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WNK2_S1862, MAP7D1_S70, and KIF1A_S1370, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ATP synthesis coupled electron transport activity versus WNK2_S1862 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WNK2_S1862 →	+1.034	+0.036	<.001	<.001	3	6
HNSC	MAP7D1_S70 →	-0.549	-0.077	<.001	<.001	3	5
BRCA	KIF1A_S1370 →	+1.629	+0.031	<.001	<.001	3	5
GBM	SHTN1_S101 →	+0.927	+0.051	.002	<.001	3	4
LSCC	SRCIN1_S165 →	+1.043	+0.032	.002	.004	3	4
GBM	ATPAF1 →	+0.370	+0.068	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042773 vs WNK2_S1862 — LSCC

Explore this scatter interactively →