ATP synthesis coupled electron transport

Across TCGA pan-cancer cohorts, RNA activity of the ATP synthesis coupled electron transport pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 101 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ATP synthesis coupled electron transport pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and LIHC, show the opposite pattern, with higher activity associated with better survival.

KIRC, UVM, and BLCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.498	0.726	<.001	146	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	62	view →
BLCA	OS	Tertile	All	0.762	0.590	.006	48	view →
LIHC	OS	Tertile	III,IV	1.000	0.596	<.001	40	view →
ACC	OS	Tertile	III,IV	0.317	0.694	.001	29	view →
KICH	DFS	Quartile	All	0.691	0.985	.022	21	view →
CESC	OS	Quartile	All	0.884	0.691	.001	20	view →
MESO	DFS	Tertile	All	0.891	0.261	.010	18	view →
ESCA	DFS	Quartile	All	0.403	0.637	.006	16	view →
CHOL	OS	Tertile	III,IV	0.193	0.819	.045	15	view →
BRCA	OS	Tertile	II,III,IV	0.645	0.448	.007	14	view →
THYM	OS	Median	All	0.794	1.000	.015	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0042773–KIRC (DFS)

Open the KIRC breakdown →