ATP synthesis coupled electron transport

Across TCGA patient cohorts, RNA activity of the ATP synthesis coupled electron transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD9, FBN1, and ACOT9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ATP synthesis coupled electron transport activity versus STARD9 in LSCC (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STARD9 →	-0.541	-0.131	<.001	<.001	3	6
LSCC	FBN1 →	-1.027	-0.176	<.001	<.001	3	6
LSCC	ACOT9 →	-0.408	-0.180	<.001	<.001	3	6
CCRCC	GPT →	+0.695	+0.103	.003	.003	3	6
LSCC	COL15A1 →	-1.121	-0.173	<.001	<.001	3	6
OV	CYC1 →	+0.738	+0.226	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042773 vs STARD9 — LSCC

Explore this scatter interactively →