ATP synthesis coupled electron transport

Across TCGA cell cohorts, RNA activity of the ATP synthesis coupled electron transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP57, CASP1, and CEACAM5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP57 grouped by ATP synthesis coupled electron transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CEP57 →	-0.576	-0.294	.009	<.001	3	4
OESOPHAGUS	CASP1 →	-2.323	-0.280	.008	.009	3	4
BREAST	CEACAM5 →	+2.019	+0.341	.003	.002	3	4
SKIN	MDM2 →	+1.025	+0.202	.003	.004	3	4
BREAST	ZSCAN12 →	-0.652	-0.326	.007	.004	3	4
BREAST	TRIAP1 →	+0.634	+0.390	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP57 by ATP synthesis coupled electron transport activity — OVARY

Explore this box plot interactively →