Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHB6, SF3A3, and KCTD11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPHB6 grouped by Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EPHB6 →	-0.218	-0.091	.002	.005	3	4
PANCREAS	SF3A3 →	-0.371	-0.099	<.001	.003	3	4
BREAST	KCTD11 →	-0.235	-0.056	.007	.007	3	4
LUNG_NSCLC_LUAD	C1QTNF1 →	+0.194	+0.079	.005	.002	3	4
LIVER	IL3RA →	-0.365	-0.137	.004	<.001	3	4
OESOPHAGUS	TPP1 →	+0.165	+0.101	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPHB6 by Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator activity — PANCREAS

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