Signal transduction in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Signal transduction in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAU, GOLGA8N, and SFXN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction in response to DNA damage activity versus PLAU in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PLAU →	+3.633	+0.285	<.001	.005	3	4
BLOOD_Leukemia	GOLGA8N →	+2.449	+0.144	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SFXN3 →	+1.022	+0.187	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	C10orf55 →	+1.245	+0.246	.002	.004	3	4
KIDNEY	GTPBP2 →	+0.969	+0.194	.003	.005	2	5
BREAST	ERRFI1 →	+1.355	+0.145	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042770 vs PLAU — BONE

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