Positive regulation of circadian rhythm

Across TCGA cell cohorts, RNA activity of the Positive regulation of circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGX, C1orf74, and CYLD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIGX grouped by Positive regulation of circadian rhythm-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PIGX →	-0.988	-0.280	.004	.001	3	4
KIDNEY	C1orf74 →	+0.346	+0.312	.002	<.001	3	4
BLOOD_Myeloma	CYLD →	-1.560	-0.415	.002	<.001	3	4
LUNG_NSCLC_LUAD	MTMR9 →	-0.572	-0.354	<.001	.007	3	4
STOMACH	DMXL2 →	-1.625	-0.362	.002	<.001	3	4
STOMACH	CSNK1G2 →	-0.974	-0.321	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIGX by Positive regulation of circadian rhythm activity — PANCREAS

Explore this box plot interactively →