Hydrogen peroxide catabolic process

Across TCGA cell cohorts, RNA activity of the Hydrogen peroxide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAT, SLC25A1, and SLC25A11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrogen peroxide catabolic process activity versus CAT in LARGE_INTESTINE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CAT →	+1.119	+0.218	<.001	.001	3	6
LIVER	SLC25A1 →	+0.822	+0.234	<.001	<.001	3	5
STOMACH	SLC25A11 →	+0.829	+0.145	.001	.006	3	5
LIVER	MAN2B2 →	+1.585	+0.348	<.001	.001	3	5
URINARY_TRACT	SEPHS2 →	+0.995	+0.298	.002	.001	3	5
OESOPHAGUS	RAC3 →	+1.817	+0.305	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042744 vs CAT — LARGE_INTESTINE

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