Hydrogen peroxide metabolic process

Across TCGA cell cohorts, RNA activity of the Hydrogen peroxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSAD1, CST6, and NDUFS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrogen peroxide metabolic process activity versus RSAD1 in OESOPHAGUS (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RSAD1 →	+1.142	+0.275	.001	.005	3	5
LARGE_INTESTINE	CST6 →	-3.241	-0.204	<.001	<.001	3	5
PANCREAS	NDUFS1 →	+0.600	+0.184	<.001	<.001	3	5
LUNG_NSCLC_LUSC	IER3IP1 →	+1.910	+0.371	<.001	.001	3	5
CNS	MIGA2 →	+0.427	+0.216	.004	<.001	3	5
LUNG_NSCLC_LUAD	C3orf52 →	-1.317	-0.227	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042743 vs RSAD1 — OESOPHAGUS

Explore this scatter interactively →