Fibrinolysis

Across TCGA cell cohorts, RNA activity of the Fibrinolysis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE1, FOSL1, and CATSPER1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibrinolysis activity versus SERPINE1 in LUNG_NSCLC_LUSC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SERPINE1 →	+6.190	+1.255	<.001	<.001	3	17
BONE	FOSL1 →	+4.178	+1.905	<.001	<.001	3	16
LUNG_NSCLC_LUSC	CATSPER1 →	+1.740	+1.410	<.001	.002	3	16
OESOPHAGUS	C10orf55 →	+1.098	+1.473	.001	.003	2	17
LUNG_NSCLC_LUSC	PLAU →	+4.632	+1.349	.001	.007	2	17
BONE	LTBP2 →	+2.891	+1.748	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042730 vs SERPINE1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →