Sperm ejaculation

Across TCGA patient cohorts, RNA activity of the Sperm ejaculation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are A1BG, SERPINA3, and SERPINA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm ejaculation activity versus A1BG in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	A1BG →	+0.453	+0.070	.001	.002	3	6
PDAC	SERPINA3 →	+0.642	+0.068	<.001	<.001	3	6
UCEC	SERPINA4 →	+0.525	+0.107	<.001	<.001	3	6
BRCA	SERPINF2 →	+0.497	+0.058	<.001	.001	3	6
UCEC	SERPING1 →	+0.578	+0.089	<.001	<.001	3	6
CCRCC	SHANK3 →	+0.460	+0.086	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042713 vs A1BG — BRCA

Explore this scatter interactively →