Regulation of cell fate specification

Across TCGA patient cohorts, RNA activity of the Regulation of cell fate specification pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRA1, APBB1IP, and CCNB1IP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell fate specification activity versus LILRA1 in GBM (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LILRA1 →	-0.781	-0.365	<.001	<.001	3	6
GBM	APBB1IP →	-1.156	-0.387	<.001	<.001	3	6
LSCC	CCNB1IP1 →	+0.627	+0.196	<.001	<.001	3	5
LSCC	FBL →	+0.685	+0.337	<.001	<.001	3	5
LSCC	MS4A6A →	-0.488	-0.137	<.001	.009	3	5
LSCC	VDR →	-0.641	-0.299	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042659 vs LILRA1 — GBM

Explore this scatter interactively →